Which condition is primarily associated with restrictive cardiomyopathy?

Restrictive cardiomyopathy is a condition characterized by the rigidity of the ventricular walls, which leads to impaired diastolic filling of the heart. Among the listed conditions, amyloidosis specifically involves the deposition of amyloid protein in various organs, including the heart. This deposition causes stiffening of the heart walls, which aligns directly with the characteristics of restrictive cardiomyopathy.

In contrast, other options, such as hypertrophy of the left ventricle, while they may lead to some overlapping symptoms, are more commonly associated with conditions like hypertrophic cardiomyopathy rather than restrictive cardiomyopathy itself. Severe coronary artery disease primarily impacts the heart through ischemic processes and does not typically lead to the specific characteristic of restricted filling. Cor pulmonale is a condition related to right heart failure due to pulmonary issues and does not describe the intrinsic myocardial changes seen in restrictive cardiomyopathy.

Because amyloidosis leads to the specific myocardial changes that result in the restrictive pattern, it is the most accurate association with restrictive cardiomyopathy among the choices.