Which structural abnormality can lead to increased systolic anterior motion of the mitral valve?

Hypertrophic obstructive cardiomyopathy (HOCM) is characterized by abnormal thickening of the heart muscle, particularly affecting the interventricular septum. This condition can create a dynamic obstruction to outflow from the left ventricle, which can also cause the mitral valve to be pushed towards the left ventricular outflow tract during systole. The phenomenon of systolic anterior motion of the mitral valve occurs when the anterior leaflet moves closer to the interventricular septum during contraction, resulting in an obstruction that can exacerbate left ventricular outflow tract obstruction and potentially lead to various hemodynamic complications.

Conditions such as aortic regurgitation, left ventricular hypertrophy, and mitral valve replacement do not directly lead to this specific mechanism of systolic anterior motion in the same manner as HOCM. Aortic regurgitation primarily affects diastolic function and can ultimately lead to left ventricular dilation, but it does not inherently involve the dynamic motion of the mitral valve as seen in HOCM. Similarly, while left ventricular hypertrophy may be associated with various conditions and can contribute to some changes in mitral valve function or position, it does not typically cause the anterior motion observed in HOCM. Mitral